Table 4.
Univariate transfer function modelsa
| Consumption of antimicrobial agent(s) | XDR-PA |
34MRGN-PA |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lag | ω | P value | NT | BIC | MSE | Lag | ω | P value | NT | BIC | MSE | |
| Meropenem | − | − | − | − | − | − | 1 | 0.28 | <0.001 | − | 207.3 | 9 |
| Piperacillin-tazobactam | − | − | − | − | − | − | 0 | 0.15 | 0.011 | AR 1 | 215.6 | 8.9 |
| Ceftriaxone | − | − | − | − | − | − | 1 | 0.6 | 0.001 | AR 1 | 207.6 | 8.3 |
| ESC | 0 | 0.27 | <0.001 | − | 186.8 | 4.7 | 1 | 0.35 | <0.001 | − | 206.2 | 8.7 |
| Cefepime | 0 | 0.51 | <0.001 | − | 185.8 | 4.6 | 0 | 0.6 | <0.001 | − | 211.2 | 8.7 |
| Cephalosporins | 0 | 0.04 | <0.001 | − | 186.4 | 4.7 | 0 | 0.05 | <0.001 | − | 210.5 | 8.6 |
| Amoxicillin-clavulanate | 0 | 0.07 | 0.052 | AR 1+4 | 193.3 | 4.6 | − | − | − | − | − | − |
a
XDR-PA, extensively drug-resistant Pseudomonas aeruginosa; 34MRGN-PA, three- and four-class-resistant Pseudomonas aeruginosa; ESC, expanded-spectrum cephalosporins; Lag, time lag in quarters; ω, parameter estimate; NT, noise term; BIC, Bayesian information criterion; MSE, mean squared error; −, no significant parameter estimate; AR, autoregressive component.