Table 3.
Dose and T>MIC values for stasis and 1-log kill and the maximum extent of killing with 6-hourly dosing of ceftolozane against four wild-type Enterobacteriaceae strains and four P. aeruginosa strainsa
| Organism | Static dose (mg/kg/6 h) | T>MIC (%) | 1-Log kill dose (mg/kg/6 h) | T>MIC (%) | Maximal killing (log10 CFU/thigh) |
|---|---|---|---|---|---|
| Wild-type Enterobacteriaceae strains | |||||
| E. coli ATCC 25922 | 38.7 | 28.1 | 75.6 | 32.8 | –2.95 |
| E. coli NIH-J | 5.69 | 28.0 | 14.3 | 32.3 | –2.49 |
| K. pneumoniae ATCC 43816 | 61.2 | 25.2 | 127 | 32.0 | –2.52 |
| K. pneumoniae 216 | 36.0 | 24.0 | 76.6 | 29.2 | –2.42 |
| Mean | 26.3 ± 2.1 | 31.6 ± 1.6 | –2.60 ± 0.24 | ||
| P. aeruginosa strains | |||||
| P. aeruginosa ATCC 27853 | 21.3 | 24.3 | 88.5 | 33.9 | –1.92 |
| P. aeruginosa 4034A | 41.5 | 28.5 | 119 | 35.3 | –2.61 |
| P. aeruginosa PO2 | 12.2 | 21.7 | 50.5 | 30.1 | –2.24 |
| P. aeruginosa 313 | 21.4 | 21.4 | 51.9 | 26.7 | –2.99 |
| Mean | 24.0 ± 3.3 | 31.5 ± 3.9 | –2.44 ± 0.46 | ||
| Mean for all strains | 25.2 ± 2.8 | 31.5 ± 2.8 | –2.52 ± 0.35 |
a
Mean values are expressed as means ± the standard errors of the mean.