Table 1.
Reference ranges of lymphocyte subsets obtained from 273 healthy blood and apheresis donors
| Parametera | Result from: |
||||
|---|---|---|---|---|---|
| Present study |
1996 study by Kam et al. (12) | ||||
| Total (n = 273) | Male (n = 150) | Female (n = 123) | P value for male vs femaleb | ||
| Age (yr) | |||||
| Mean | 36.5 | 40 | 33 | 32 | |
| Median | 37 | 42 | 29 | ||
| SD | 11.3 | 10 | 11 | ||
| No. of CD3+ cells/μl (%) | |||||
| Mean | 1,362 (71.15) | 1,316 (70) | 1,418 (72.52) | ||
| SD | 382 (6.78) | 354 (7.33) | 407 (5.78) | ||
| Reference range | 723–2,271 (56.09–84.32) | 721–2,102 (53.01–84.04) | 710–2,363 (61.51–84.39) | 0.027* (0.002*) | 672–2,368 (54.8–83) |
| No. of CD3+ CD4+ cells/μl (%) | |||||
| Mean | 760 (40.25) | 735 (39.69) | 790 (40.93) | ||
| SD | 233 (6.36) | 220 (6.62) | 245 (5.99) | ||
| Reference range | 396–1,309 (28.06–53.39) | 393–1,279 (26.58–53.13) | 397–1,320 (29.71–53.84) | 0.52 (0.108) | 292–1,366 (23.1–51) |
| No. of CD3+ CD8+ cells/μl (%) | |||||
| Mean | 515 (27.24) | 496 (26.71) | 539 (28.88) | ||
| SD | 192 (6.62) | 196 (7.46) | 185 (5.37) | ||
| Reference range | 224–1,014 (16.37–42.65) | 219–1,015 (15.14–45.99) | 239–1,039 (17.52–40.81) | 0.68 (0.146) | 240–1,028 (17.9–47.5) |
| No. of CD19+ cells/μl (%) | |||||
| Mean | 298 (15.35) | 296 (15.42) | 300 (15.27) | ||
| SD | 124 (4.54) | 130 (4.86) | 116 (4.12) | ||
| Reference range | 118–645 (7.19–25.85) | 92–671 (6.83–25.76) | 121–634 (8.27–26.07) | 0.791 (0.794) | 82–560 (5.1–20.8) |
| No. of CD56+ cells/μl (%) | |||||
| Mean | 229 (11.78) | 247 (12.81) | 207 (10.52) | ||
| SD | 132 (5.69) | 149 (6.42) | 106 (4.35) | ||
| Reference range | 61–607 (3.66–26.74) | 82–648 (4.76–32.08) | 53–525 (3.31–21.94) | 0.013* (0.001*) | 130–938 (7.1–38) |
| CD4/CD8 cell ratio | |||||
| Mean | 1.59 | 1.64 | 1.55 | ||
| SD | 0.55 | 0.61 | 0.47 | ||
| Reference range | 0.71–2.82 | 0.70–2.97 | 0.78–2.92 | 0.21 | 0.5–1.8 |
a
Reference ranges are defined as 95% of the population.
b
P values for comparison of the male and female populations are shown. *, statistically significant result.