Domain structure of P. tetraurelia Stomatins. Schematic presentation of P. tetraurelia Stomatin domain architecture and those of various mammalian SPFH proteins. SPFH and SCP-2 domains, hydrophobic domains (called a transmembrane domain by some), and EA repeats (absent from P. tetraurelia Sto [PtSto]) are indicated. Sequences used are the following: GSPATP00013742001 (PtSto1ap), GSPATP00018485001 (PtSto1bp), GSPATP00027276001 (PtSto1cp), GSPATP00034033001 (PtSto1dp), GSPATP00024614001 (PtSto2ap), GSPAT00010097001 (PtSto2bp), GSPATP00004121001 (PtSto2cp), GSPATP00018907001 (PtSto3ap), GSPATP00024437001 (PtSto3bp), GSPATP00030747001 (PtSto4ap), GSPATP00021746001 (PtSto4bp), GSPATP00026272001 (PtSto4cp), GSPATP00033325001 (PtSto5ap), GSPATP00022578001 (PtSto5bp), GSPATP00012426001 (PtSto5cp), GSPATP00016343001 (PtSto5dp), GSPATP00015155001 (PtSto6p), GSPATP00020490001 (PtSto7p), GSPATP00020414001 (PtSto8ap), GSPATP00023643001 (PtSto8bp), AAH10703.1 (Homo sapiens Stom [HsStom]), AAH37074.1 (Mus musculus SLP-1 [MmSLP-1]), NP_075720.1 (MmSLP-2), NP_002625.1 (HsProh), AAD40192.1 (HsFlot-1), and NP_663477 (MmErlin1). All Paramecium sequence accession numbers are from ParameciumDB (http://paramecium.cgm.cnrs-gif.fr/page/index).