Table 1.
Heterozygous loci in E. cuniculi genotypes I, II, and III
| Genotype | Gene | Product | Polymorphism type | Protein effect | Nucleotide change | Amino acid change | Position in coding sequence |
|---|---|---|---|---|---|---|---|
| I | ECU02_0050 | Hypothetical protein | SNP (transversion) | None | C/A | 1738 | |
| ECU02_0050 | Hypothetical protein | SNP (transition) | Substitution | G/A | R → W | 1736 | |
| ECU02_0260 | GATA zinc finger transcription factor 3 | SNP (transition) | Truncation | C/T | 60 | ||
| ECU02_0720 | Histone H2A | SNP (transition) | None | A/G | 221 | ||
| ECU05_1190 | Belongs to the ABC transporter superfamily | SNP (transition) | None | A/G | 381 | ||
| ECU06_0470 | Nuclear pore complex protein nup155 | SNP (transition) | None | A/G | 2656 | ||
| Intergenic_ch6 | SNP (transversion) | A/C | |||||
| ECU06_0590 | Hypothetical protein | Indel | Frameshift | C/- | 655 | ||
| ECU06_0700 | Hypothetical protein | Indel | Frameshift | CC/- - | 429 | ||
| ECU06_0730 | Ribonucleoside diphosphate reductase small chain | SNP (transition) | None | G/A | 719 | ||
| ECU06_0830 | Hypothetical protein | SNP (transversion) | Substitution | C/A | M → I | 1711 | |
| ECU07_1005 | 60S ribosomal protein l37a | SNP (transition) | None | A/G | 252 | ||
| ECU11_1160 | Possible protein of nuclear scaffold | SNP (transition) | None | C/T | 609 | ||
| ECU11_1330.6 | Transcription factor (forkhead domain) | Indel | Frameshift | A/- | 692 | ||
| ECU11_1330.1 | Transcription factor (forkhead domain) | SNP (transition) | None | G/A | 511 | ||
| ECU11_1330.2 | Transcription factor (forkhead domain) | SNP (transition) | None | T/C | 457 | ||
| ECU11_1330.2 | Transcription factor (forkhead domain) | SNP (transition) | Substitution | C/T | D → N | 452 | |
| ECU11_1330.3 | Transcription factor (forkhead domain) | SNP (transition) | None | A/G | 368 | ||
| ECU11_1330.4 | Transcription factor (forkhead domain) | SNP (transition) | None | A/G | 232 | ||
| ECU11_1330.5 | Transcription factor (forkhead domain) | SNP (transition) | Substitution | C/T | A → T | 108 | |
| Intergenic_ch11 | SNP (transition) | C/T | |||||
| ECU11_1340 | ABC transporter-like protein | Indel | Frameshift | -/A | 1890 | ||
| ECU11_1340 | ABC transporter-like protein | SNP (transversion) | Substitution | T/A | I → F | 1020 | |
| II | ECU04_0440 | Metal-dependent protease of the Pad1 Jab1 | SNP (transition) | None | T/C | 908 | |
| ECU05_0720 | Splicing factor U2AF large subunit b | SNP (transition) | Substitution | A/G | R → C | 1012 | |
| ECU06_0700 | Hypothetical protein | SNP (transition) | None | C/T | 413 | ||
| ECU07_0680 | Chromosome segregation ATPase | SNP (transition) | None | G/A | 564 | ||
| ECU07_0770 | Npl4 family protein | SNP (transition) | Substitution | A/G | H → Y | 433 | |
| ECU07_1490 | Copper amine oxidase N-terminal domain protein | SNP (transition) | None | C/T | 267 | ||
| ECU07_1500 | Calcium-transporting ATPase | SNP (transition) | None | A/G | 1857 | ||
| ECU08_0080 | Dihydrofolate reductase | Indel | Frameshift | T/- | 94 | ||
| ECU08_0230 | Cell division protein kinase | SNP (transition) | None | T/C | 186 | ||
| ECU08_1010 | Proteophosphoglycan Ppg4 | SNP (transition) | Substitution | G/A | I → M | 768 | |
| ECU08_1730 | Hypothetical protein | SNP (transversion) | Substitution | T/G | H → N | 241 | |
| ECU09_0360 | Similarity to hypothetical proteins (Upf0129 family) | SNP (transversion) | None | A/C | 272 | ||
| ECU09_0410 | DNA excision repair protein Ercc-6 | SNP (transition) | Substitution | C/T | F → L | 1417 | |
| ECU09_0730 | Bem46 family protein | SNP (transition) | Substitution | A/G | G → D | 738 | |
| ECU09_1120 | Hypothetical protein | SNP (transition) | None | C/T | 35 | ||
| ECU09_1820 | snRNP-like protein | Indel | Frameshift | G/- | 149 | ||
| ECU10_1210 | DNA polymerase catalytic subunit a | SNP (transition) | Substitution | A/G | S → F | 857 | |
| ECU11_0410 | Hypothetical protein | SNP (transition) | Substitution | C/T | N → S | 461 | |
| Intergenic_ch11 | SNP (transition) | C/T | |||||
| Intergenic_ch8.1 | SNP (transition) | G/A | |||||
| Intergenic_ch8.2 | SNP (transversion) | T/C | |||||
| Intergenic_ch10 | SNP (transition) | A/G | |||||
| III | ECU01_0410 | Hypothetical protein | SNP (transition) | Substitution | A/G | R → G | 674 |
| ECU01_0750 | Hypothetical protein | SNP (transition) | Substitution | T/C | F → S | 333 | |
| ECU03_0320 | 60S ribosomal protein l13 | SNP (transition) | None | C/T | 264 | ||
| ECU03_1180 | Subtilisin-related endopeptidase K | SNP (transition) | Substitution | G/A | P → S | 1109 | |
| ECU04_0470 | Hypothetical protein | SNP (transition) | None | A/G | 754 | ||
| ECU04_1460 | Cyclin b-like guanine nucleotide binding protein | Indel | Frameshift | T/- | 2100 | ||
| ECU04_1470 | Na+/H+ antiporter | SNP (transversion) | None | T/G | 1073 | ||
| ECU04_1490 | Hypothetical protein | SNP (transversion) | Substitution | C/A | D → Y | 1237 | |
| ECU05_0700 | Hypothetical protein | SNP (transition) | Substitution | G/A | G → R | 762 | |
| ECU05_0850 | Hypothetical protein | SNP (transition) | Substitution | C/T | G → S | 41 | |
| Intergenic_ch7.1 | SNP (transition) | T/C | |||||
| Intergenic_ch7.2 | SNP (transition) | A/G | |||||
| ECU08_1150 | Hypothetical oxidoreductase short-chain dehydrogenases/reductases (SDR) family | SNP (transversion) | Substitution | T/G | W → G | 549 | |
| ECU08_1680 | Hypothetical protein | SNP (transition) | Substitution | A/G | E → G | 597 | |
| ECU10_0540 | Similarity to ADP/ATP carrier protein | SNP (transition) | Substitution | C/T | R → K | 5 | |
| ECU10_0960 | Similarity to hypothetical proteins Ycd7_human | SNP (transition) | Substitution | A/G | S → P | 68 | |
| ECU10_1030 | Hypothetical protein | Indel | Frameshift | G/- | 1938 | ||
| ECU11_1120 | Translation elongation factor 2 | SNP (transition) | Substitution | G/A | V → M | 433 | |
| ECU11_1410 | Hypothetical protein | SNP (transition) | None | T/C | 632 | ||
| Intergenic_ch11 | SNP (transversion) | G/T | |||||
| ECU06_0630 | Hypothetical protein | SNP (transition) | Substitution | G/A | C → Y | 1472 |