Table 1.

Hypervascular lesions in noncirrhotic patients. The most important elements to achieve the differential diagnosis.

MRI features
	Risk factor and clinical setting	T2w	T1w in	T1w out	DWI	Pre-c	ArtP	PVP	EqP	HBP	Specific pattern
Inflammatory adenoma		Hyper	Hypo	Hypo	Restriction	Hypo	Hyper +	Hyper	Hyper/iso	Hypo/hyper	Signal heterogeneity, hypervascularity, intralesional hemorrhage
HNF-1α-mutated adenoma	Obesity, steatosis, diabetes, glycogenesis, exogenous steroids	Iso/hyper	Hyper	Hypo	No restriction	Iso/hypo	Hyper	Hypo	Hypo	Hypo	Fatty intralesional component
β-catenin-mutated adenoma		Hyper	Hypo	Hypo	Restriction	Hypo	Hyper +	Hyper	Hyper/iso	Hypo/hyper	Intralesional hemorrhage, necrosis
Unclassified adenoma											Nonspecific patterns reported
Focal nodular hyperplasia	Exogenous steroids	Iso	Iso	Iso	No restriction	Iso	Hyper +++	Iso	Iso	Iso/hyper	Signal homogeneity, hypervascularity, scar, iso/hyperintensity on HbP
Large regenerative nodule	Myeloproliferative and lymphoproliferative disorders, chronic vascular and rheumatologic syndromes	Iso	Iso	Iso	No restriction	Iso	Hyper ++	Iso	Iso	Iso/hyper	Multiple lesions signal homogeneity, hypervascularity, scar, isohyperintensity on HbP
HCC in noncirrhotic liver and FL-HCC	Exogenous steroidenvironmental and dietary factors (aflatoxins and nitrosamine)	Hyper	Hypo	Hypo	Restriction	Hypo	Hyper ++	Hypo	Hypo	Hypo	Signal heterogeneity, intralesional hemorrhage, signs of malignancy
Cholangiocarcinoma	Viral hepatic infection	Hyper	Hypo	Hypo	Restriction	Hypo	Hyper	Hypo	Hypo/iso	Hypo/hyper	Peripheral enhancement, peripheral washout, central pooling, signs of malignancy
Primary lymphoma	Epstein-Barr infection (EBV), HBV and/or HCV infections	Iso/hyper	Hypo	Hypo	Restriction	Hypo	Hyper	Hypo	Hypo	Hypo	Variable pattern, small lesions hypervascular, significant restriction
Metastases	Primary tumor, metastatic syndrome	Hyper	Hypo	Hypo	Restriction	Hypo	Hyper ++	Iso/hypo	Hypo	Hypo	Multiple lesions hypervascularity, halo signs signs of malignancy