Fig. 3.

Functional evaluation of quadriceps reinnervation as assessed using foot base angle (FBA). (A) Evaluation of FBA measurements over time revealed significantly reduced angles at weeks 8, 12, and 15 between collagen and saline treated groups, and between glycomimetic peptide-coupled and non-glycomimetic peptide-coupled groups. No statistical differences were found among groups treated with glycomimetic peptide-coupled collagen or between and native collagen and scrambled peptide-coupled groups at any of these time points. (B) When FBA measurements were normalized to the extent of injury at week 1 using the recovery index, statistically significant differences are seen at weeks 8, 12, and 15 between collagen and saline treated groups. No statistical differences were found among glycomimetic treated groups or between native and scrambled peptide-coupled groups at any of these time point. An asterisk (*) signifies statistically significant differences verses saline when compared to its respective time point. A double asterisk (**) signifies statistically significant differences versus saline, native, and scrambled peptide-coupled collagen when compared to its respective time point. Means are reported +/− standard error. Differences were considered significant at p < 0.05 using one-way analysis of variance.