Fig. 5.

Histomorphometry of regenerated nerve. Representative images of osmium tetroxide stained saline (A) and glycomimetic peptide-coupled collagen (B) treated cross-sections from the middle of regenerated nerves at 16 weeks post-injury. (C) Evaluation of myelinated axon number revealed significantly more axons in collagen hydrogel verses saline treated groups, and between PSA containing hydrogels and non-PSA containing hydrogels. (D) Grafts with collagen hydrogels yielded a significantly greater percentage of nerve regeneration compared to saline treated animals. No statistical differences were noted between collagen treated groups. An asterisk (*) signifies statistically significant differences when compared to saline. A double asterisk (**) signifies statistically significant differences when compared to native, scrambled peptide-coupled, and HNK-coupled groups. Means are reported +/− standard error. Differences were considered significant at p < 0.05 using one-way analysis of variance. Scale bar represents 200 μm.