Table 3.
Associations between APOE ε4 and LB, AD and vascular pathology, and brain weight
| APOE ε4 allele count | P-value | ||||
|---|---|---|---|---|---|
|
| |||||
| Outcome measure | 0 “ε4” alleles (N=348) | 1 “ε4” allele (N=331) | 2 “ε4” alleles (N=78) | No adjustment | Adjusting for age and sex |
| LB count | |||||
| Middle frontal (>0) | 94 (27%) | 105 (32%) | 21 (27%) | 0.84 | 0.85 |
| Superior temporal (>0) | 113 (33%) | 124 (37%) | 24 (31%) | 0.47 | 0.40 |
| Inferior parietal (>0) | 86 (25%) | 88 (27%) | 20 (26%) | 0.17 | 0.19 |
| Cingulate gyrus (>0) | 107 (31%) | 123 (37%) | 25 (32%) | 0.87 | 0.75 |
|
| |||||
| LBD score (≥ 2) | 110 (32%) | 121 (37%) | 25 (32%) | 0.46 | 0.44 |
|
| |||||
| NFT count | |||||
| Middle frontal | 1 (0, 0, 6, 40) | 2 (0, 0, 6, 46) | 6 (0, 2, 11, 27) | 0.003 | 0.001 |
| Superior temporal | 3 (0, 0, 10, 47) | 6 (0, 2, 12, 37) | 10 (0, 4, 16, 35) | <0.001 | <0.001 |
| Inferior parietal | 2 (0, 0, 8, 57) | 4 (0, 1, 9, 60) | 8 (0, 3, 13, 33) | 0.001 | <0.001 |
| Hippocampal CA1 | 5 (0, 2, 12, 38) | 10 (0, 3, 18, 55) | 12 (0, 7, 18, 55) | <0.001 | <0.001 |
|
| |||||
| Braak stage (≥ 5) | 192 (55%) | 241 (73%) | 72 (92%) | <0.001 | <0.001 |
|
| |||||
| SP count | |||||
| Middle frontal (<50) | 99 (28%) | 45 (14%) | 4 (5%) | <0.001 | <0.001 |
| Superior temporal (<50) | 135 (39%) | 60 (18%) | 5 (6%) | <0.001 | <0.001 |
| Inferior parietal (<50) | 103 (30%) | 41 (13%) | 3 (4%) | <0.001 | <0.001 |
| Motor cortex | 16 (0, 5, 27, 50) | 20 (0, 11, 30, 50) | 25 (0, 13, 43, 50) | <0.001 | <0.001 |
| Visual cortex | 22 (0, 7, 35, 50) | 32 (0, 18, 50, 50) | 48 (1, 24, 50, 50) | <0.001 | <0.001 |
|
| |||||
| Vascular disease | 104 (30%) | 90 (27%) | 16 (21%) | 0.11 | 0.17 |
|
| |||||
| Brain weight | 1100 (684, 1000, 1240, 1630) | 1080 (440, 960, 1160, 1540) | 1050 (680, 928, 1195, 1540) | <0.001 | 0.002 |
The sample median (minimum, 25th percentile, 75th percentile, maximum) is given for numerical variables. P-values result from negative binomial regression models (LB counts and NFT counts), parametric regression survival models considering counts of 50 censored (SP counts), logistic regression models (LBD score ≥ 2, vascular disease, Braak stage ≥ 5), and linear regression models (brain weight), under an additive model.
P-values ≤ 0.0056 are considered statistically significant after a single-step minP adjustment for multiple testing. Numbers account for genotype failure. LB = Lewy body, LBD = Lewy body disease, NFT = neurofibrillary tangle, SP = senile plaque.