Figure 4.

Correlation analysis between the MIF and CXCR4 expressions in different cell populations and survival curves for ESCC patients according to their expression levels of MIF and CXCR4 in tumor cells. (A) The expression levels of MIF and CXCR4 in tumor cells were significantly positively correlated (P = 0.009, R = 0.224). (B) The expression levels of MIF and CXCR4 in TILs were significantly positively correlated (P = 0.026, R = 0.191). (C and D) Disease-free survival and overall survival curves for patients according to the combined low expression level, single high and combined high expression level of MIF and CXCR4 in tumor cells and TILs.