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. 2013 Apr 11;9(4):e1003302. doi: 10.1371/journal.ppat.1003302

Figure 6. Model: TIP47 recruits LD membranes to the membranous web via interaction with NS5A.

Figure 6

In uninfected cells: TIP47 is involved in the retrograde trafficking pathway by interacting with Rab9 at late endosomes, and functions as an “exchangeable” LD-associated protein that is mostly present in the cytosol but moves to LDs upon rapid fat storage. In HCV-infected cells: TIP47 interacts with NS5A-containing replication complexes at the ER and NS5A at LDs, thus making LD membranes accessible for HCV RNA replication for either integration of LDs into the membranous web, or as source of energy for the creation of the membranous web. HCV infection also increases endosome-to-Golgi trafficking via the up-regulation of Rab9 expression.