Table 2. Neuropsychological data of relapsing-remitting multiple sclerosis (RR-MS) patients and healthy controls (HC).
| RR-MS Val66 | RR-MS Met66 | HC Val66 | HC Met66 | MainEffect of Group | MainEffect of Genotype | Groupby Genotype Interaction | ||||||
| Function | Neuropsychological Test | Mean | SD | Mean | SD | Mean | SD | Mean | SD | F; P values | F; P values | F; P values |
| Global Cognition | WAIS-R IQ total score | 100.4 | 18.5 | 103.5 | 17.9 | 116.1 | 9.4 | 107.2 | 23.2 | F = 2.8; P = 0.1 | F = 0.9; P = 0.3 | F = 2.5; P = 0.1 |
| Information Processing | WAIS-R Digit Symbol | 7.0 | 2.6 | 8.6 | 2.7 | 11.7 | 2.7 | 10.9 | 3.5 | F = 20.1; P = 0.001 | F = 0.0; P = 0.9 | F = 2.2; P = 0.1 |
| Executive Functions | MCST-CA | 5.7 | 0.5 | 5.8 | 0.01 | 5.8 | 0.01 | 5.7 | 0.5 | F = 0.0; P = 0.9 | F = 0.0; P = 0.9 | F = 2.0; P = 0.1 |
| MCST-PE | 2.0 | 1.9 | 1.5 | 2.5 | 2.9 | 2.0 | 2.6 | 3.1 | F = 1.9; P = 0.2 | F = 0.5; P = 0.5 | F = 0.0; P = 0.9 | |
| Verbal Memory | RAVLT | 39.9 | 10.3 | 38.2 | 8.3 | 39.5 | 4.2 | 42.7 | 7.9 | F = 0.5; P = 0.5 | F = 0.01; P = 0.9 | F = 0.6; P = 0.4 |
| Visuo-spatial skills | Benton JLO | 25.2 | 3.1 | 24.7 | 4.0 | 25.4 | 3.1 | 24.9 | 4.0 | F = 0.1; P = 0.7 | F = 0.8; P = 0.4 | F = 0.1; P = 0.7 |
| Visuo-spatial Memory | ROCFT | 14.1 | 5.5 | 16.9 | 5.7 | 19.7 | 6.6 | 20.1 | 3.3 | F = 9.6; P = 0.01 | F = 0.0; P = 0.8 | F = 0.4; P = 0.5 |
| Working-Memory | Digit Span Forward | 5.7 | 1.7 | 6.0 | 1.6 | 7.1 | 1.8 | 6.6 | 2.2 | F = 1.8; P = 0.2 | F = 0.9; P = 0.3 | F = 0.5; P = 0.5 |
| Digit Span Backward | 4.7 | 1.6 | 5.0 | 1.3 | 5.5 | 2.3 | 6.4 | 3.4 | F = 1.5; P = 0.2 | F = 0.1; P = 0.7 | F = 0.0; P = 0.8 | |
| Verbal Fluency | COWAT | 29.6 | 7.5 | 28.9 | 9.0 | 29.8 | 12.9 | 35.6 | 8.6 | F = 0.3; P = 0.6 | F = 0.0; P = 0.8 | F = 1.4; P = 0.2 |
| Anxiety | Hamilton Anxiety Scale | 20.5 | 5.0 | 19.9 | 7.2 | 15.5 | 4.6 | 17.2 | 5.5 | F = 4.2; P = 0.06 | F = 0.0; P = 0.8 | F = 1.8; P = 0.2 |
| Depression | CMDI | 74.0 | 25.3 | 72.4 | 20.9 | 66.5 | 16.0 | 73.7 | 22.1 | F = 0.0; P = 0.9 | F = 0.2; P = 0.6 | F = 1.5; P = 0.2 |
Legend. Standard Deviation (SD); WAIS-R: Wechsler Adult Intelligence Scale-Revised; IQ: Intelligence Quotient; Modified Card Sorting Test (MCST), CA: Correct Answers; PE: Perseverative Errors; Rey Auditory Verbal Learning Test (RAVLT); JLO: Judgment of Lines Orientation; ROCFT: Rey-Osterrieth Complex Figure Test; COWAT: Controlled Oral Word Association Test; CMDI: Chicago Multiscale Depression Inventory.