Table 2.
Surgery for Primary Hyperparathyroidism in Sporadic, MEN1 and MEN2A
| Characteristics | Sporadic pHPT, n = 467 | MEN1-pHPT, n = 52 | MEN2A-pHPT, n = 16 |
|---|---|---|---|
| Initial operation, n |
|
|
|
| Minimally invasive parathyroidectomy |
328 (70%) |
5 (10%) |
6 (38%) |
| Minimally invasive parathyroidectomy converted to conventional neck exploration |
39 (8%) |
3 (6%) |
0 |
| Conventional neck exploration |
100 (21%) |
44 (84%) |
10 (62%) |
| Subtotal parathyroidectomy, n |
- |
38 (73%) |
- |
| Total parathyroidectomy, n |
- |
6 (12%) |
- |
| Number of operations, n |
|
|
|
| One procedure |
435 (93%) |
26 (50%) |
13 (81%) |
| Two procedures |
31 (7%) |
17 (33%) |
1 (6%) |
| Three or more procedures |
1 (<1%) |
9 (17%) |
2 (13%) |
| Mean number of operations |
1.07 |
1.85 |
1.29 |
| Cumulative operative findings, n |
|
|
|
| No adenoma found |
6 (1%) |
- |
1 (6%) |
| 1 enlarged gland |
426 (91%) |
17 (33%) |
13 (81%) |
| Solitary (adenoma, hyperplasia) |
422 (90%) |
17 (33%) |
13 (81%) |
| Carcinoma |
4 (1%) |
- |
- |
| > 1 enlarged glands |
35 (7%) |
35 (56%) |
2 (13%) |
| 2 enlarged glands |
26 (6%) |
12 (23%) |
2 (13%) |
| 3 enlarged glands |
8 (2%) |
17 (33%) |
- |
| > 3 enlarged glands or hyperplasia | 1 (<1%) | 6 (12%) | - |
Abbreviations: pHPT, primary hyperparathyroidism; MEN1, multiple endocrine neoplasia type 1; MEN2A, multiple endocrine neoplasia type 2A. Subtotal parathyroidectomy; (less than) SPTX. Total parathyroidectomy; TPTX.