Table 2.
Genetic polymorphisms in non-androgen associated genes with differential racial frequencies
| Gene | Variant | Racial frequency difference | Association with prostate cancer risk | ||
|---|---|---|---|---|---|
|
| |||||
| Asian | White | Black | |||
| EGFR | CA repeat | Longer in Asians than whites and blacks | NA | NA | NA |
| RNASEL | Arg462Gln | More in Caucasians than Asians and African-Americans | IC | IC | IC |
| Asp541Glu | Less Asp allele homozygote in Asians than Caucasians and Africans | IC | IC | IC | |
| ELAC2 | Ser217Leu | More in Caucasians than Asians and blacks | Yes | No | Yes |
| Ala541Thr | More in Caucasians than Asians and blacks | Yes | No | No | |
| XRCC1 | G>A (rs25487) | Similar in Asian and Whites, but higher than African descents | Yes | No | No |
| CDH1 | -160 C/A | Higher in whites and blacks than Asians | IC | IC | No |
| VDR | TaqI | Lowest in Asians | IC | IC | IC |
| ApaI | More in Asians than Caucasians and Africans | IC | IC | IC | |
| Poly(A) | Lowest in Asians | No | No | No | |
| BsmI | Lower in Asians than other populations | IC | IC | IC | |
| FokI | More in Asians than Caucasians and Africans | IC | IC | Yes | |
NA: no report in the population; IC: Inconclusive.