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. 2013 Apr 11;8(4):e60919. doi: 10.1371/journal.pone.0060919

Figure 1. SDF-1α is elevated in wound fluid and increases tumor growth.

Figure 1

A. SDF-1α levels in wound fluid from BALB/c wildtype (WT) mice were higher than in wound fluid from BALB/c nu/nu mice (nu/nu) or plasma from BALB/c WT animals (cytokine microarray). B. SDF-1α levels in wound fluid from BALB/c WT animals increased during the course of wound healing and were higher in WT wound fluid than in wound fluid from nu/nu animals 9d after wounding (insert). n = 5 samples/time point (0.3d to 5d) and n = 3 samples/time point (5d to 14d); Triangle: mean; filled circle: individual data point. Insert: p = 0.05, n = 3, Mann Whitney test). C, D. Inhibition of SDF-1α/CXCR4 signaling by AMD3100 treatment abolished wound-promoted-tumor growth. C. Experimental design. D. Cumulative tumor volumes. p = 0.0027, n = 10 animals/group, Kruskal Wallis Test/Dunn’s Multiple Comparison Test, observation time: 21d, mean ±95% CI.