Table 2.
| Ratio of uncoupled to coupled A1AR |
t-test | |||||
|---|---|---|---|---|---|---|
| ct12 | sd12 | ct24 | sd24 | sd12 vs ct12 |
sd24 vs ct24 |
|
| Cerebellum | 2.2 ± 0.3 | 2.6 ± 0.4 | 2.6 ± 0.3 | 2.4 ± 0.4 | 0.09 | 0.36 |
| Cortex M1 | 1.6 ± 0.2 | 2.1 ± 0.2 | 2.3 ± 0.4 | 2.2 ± 0.3 | 0.01 | 0.53 |
| Cortex Par | 1.7 ± 0.2 | 2 ± 0.2 | 2.5 ± 0.2 | 2.3 ± 0.1 | 0.04 | 0.08 |
| Cingulate ctx. | 2.1 ± 0.3 | 2.7 ± 0.3 | 2.8 ± 0.4 | 2.9 ± 0.2 | 0.01 | 0.74 |
| Hippocampus | 1.6 ± 0.2 | 2 ± 0.4 | 2.3 ± 0.3 | 2.1 ± 0.2 | 0.16 | 0.36 |
| Dentate gyrus | 1.6 ± 0.2 | 2.1 ± 0.5 | 2.3 ± 0.4 | 2.3 ± 0.2 | 0.09 | 0.91 |
| Thalamus | 1.7 ± 0.3 | 2.2 ± 0.5 | 2.3 ± 0.3 | 2.3 ± 0.2 | 0.11 | 0.95 |
| Hypothalamus | 2.4 ± 0.8 | 3.1 ± 0.9 | 3.3 ± 0.9 | 3.1 ± 0.6 | 0.32 | 0.64 |
| Caudate-putamen | 1.8 ± 0.3 | 2.5 ± 0.2 | 2.8 ± 0.5 | 2.7 ± 0.2 | 0.002 | 0.64 |
| Ncl. accumbens | 2.3 ± 0.6 | 3.8 ± 0.5 | 3.8 ± 1.1 | 3.3 ± 0.6 | 0.002 | 0.40 |
Ratios of A1 adenosine receptors uncoupled (addition of Gpp(NH)p to buffer) and coupled (addition of MgCl2 to the buffer) to the G-protein in various rat brain regions of the 12 and 24 h sleep deprivation (sd) group and of the circadian control (ct) group. Values are means ± standard deviation; results of statistical testing with Students t-test are reported; p<0.05 values are highlighted in bold numbers.