Table 1.

Mice: Behavior (mean±sem) of vehicle-administered WT (n=15) or estrogen receptor β knockout (βERKO; n=21) mice, 3β-diol-administered WT (n=11) or βERKO (n=34) mice, 3α-diol-administered WT (n=13) or βERKO (n=34) mice or androsterone (Androst) administered WT (n=12) or βERKO (n=29)

	Condition	OF-total entries	EPM-total open arm entries	EPM-% open arm time	EPM-% open arm entries
Wildtype mice*	Vehicle	94.7±6.8	3.2±0.5	1.0± 0.4	6.9±2.5
	3β-diol	112.3±11.2	3.9±0.4	8.0±2.5**	26.6±4.1**
	3α-diol	107.4±6.4	5.0±0.5	5.1±1.2**	21.3±3.6**
	Androsterone	102.8±8.4	4.2±0.6	5.4±1.5**	20.1±3.3**
βERKO mice	Vehicle	146.9±8.8	7.7±1.2	2.1±0.4	13.5±2.4
	3β-diol	162.4±4.6	9.6±1.4	2.3±0.6	11.1±1.9
	3α-diol	164.5±10.5	10±1.3	2.5±0.8	10.1±2.4
	Androsterone	131.6±4.1	10.8±1.2	4.8±0.8	15.9±2.1
Rats	Vehicle	119.9±4.9	7.7±0.8	0.4±0.2	5.1±2.7
	3β-diol	118.1 ±3.9	9.6±1.4	4.2±1.4**	17.4±4.1**
	3α-diol	121.9±5.9	8.1±0.6	3.2±0.8**	16.9±3.3**
	Androsterone	126.6±4.9	7.8±0.5	4.5±1.1**	20.1±3.3**

Rats: behavior (mean±sem) of vehicle administered (n=22), 3β-diol-administered (n=26), 3α-diol-administered (n=25) or Androst administered (n=25).

^*Denotes significance <0.05 compared to βERKO knockout mice.

^**Denotes significance <0.05 compared to vehicle administration.