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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Psychopharmacology (Berl). 2012 Dec 28;227(1):127–136. doi: 10.1007/s00213-012-2946-z

Table 2. Experiment 2.

Effects of repeated administration (5-day) of vehicle (V) and doses of 3-PBC (10-min pretreatment) on seeking (C2-L1, C2-L2) for alcohol (Alcohol Group) and a non-alcohol beverage (Control Group) under the CSR. All data are the mean of days 3-5 of each condition. BL is the grand mean of the 3 baseline days preceding each chronic condition.

3-PBC Dose
Alcohol Group BL V 1.0 3.0 10.0 18.0 F(5,15)
C2-L1 Left Lev FI Resp Mean 144.7 169.4 106.9 115.5 36.8 116.3 0.48
SEM 84.8 102.8 60.1 84.0 23.7 50.3
Left Lev FI Resp Latency (s) Mean 630.2 606.2 695.8 712.3 697.8 739.0 1.60
SEM 13.7 2.1 53.4 35.0 32.3 57.6
C2-L2 Left Lev FR Resp Rate (r/s) Mean 3.1 3.2 2.7 2.2 2.1 2.1 1.40
SEM 0.3 0.5 0.5 0.3 0.7 0.7
C3 Volume (ml) Mean 625.6 674.8 576.7 489.6 355.4 283.3 4.86
SEM 31.2 85.1 115.0 110.6 76.5 71.2
g.kg Alc consumed Mean 1.13 1.12 1.00 0.90 0.67 0.48 3.85
SEM 0.1 0.1 0.2 0.1 0.2 0.1
Control Group
C2-L1 Left Lev FI Resp Mean 93.4 234.5 306.7 115.4 74.2 101.3 5.30
SEM 21.5 73.8 129.1 44.3 49.4 72.6
Left Lev FI Resp Latency (s) Mean 606.8 610.7 616.4 710.1 711.0 676.9 0.96
SEM 0.9 2.52 12.4 56.2 87.8 70.1
C2-L2 Left Lev FR Resp Rate (r/s) Mean 3.1 2.9 2.5 2.1 1.5 1.7 3.78
SEM 0.3 0.4 0.2 0.2 0.3 0.4
C3 Volume (ml) Mean 1000 1000 979.2 825.0 772.9 775.0 1.84
SEM 0.0 0.0 20.8 175.0 88.2 125.2

Data shown are group means (and SEM) for baseline (BL) and each 3-PBC dose (mg/kg). FI, Fixed Interval; FR, Fixed Ratio; Lev, Lever; Resp, Response; Alc, Alcohol

1An underlined F ratio indicates a significant (p<0.05 ANOVA); bolded numbers indicate a significant p<0.05) Bonferroni's post-hoc test compared to vehicle.