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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Eur J Clin Pharmacol. 2012 Sep 28;69(4):851–857. doi: 10.1007/s00228-012-1410-7

Table 1.

Summary of Pharmacokinetic Parameters (Mean ± SD) for APAP Protein Adducts following administration of Immediate and Extended Release formulations.

Immediate Release Extended Release
Tmax (hr) 8.4 ± 1.9 8.6 ± 3.4
Cmax (μM) 0.108 ± 0.020 0.100 ± 0.028
AUC0-12 (μM*hr) 0.95 ± 0.17 0.85 ± 0.21
Half life (hr) 23.4 ± 21.7a 21.0 ± 14.0b
MRT (hr) 36.8 ± 30.9a 33.3 ± 20.1b
formation rate (1/hr)c 0.420 ± 0.157b 0.203 ± 0.080b
a

n=7 subjects;

b

n=6 subjects;

c

p=0.035