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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Bone. 2013 Jan 23;54(2):230–236. doi: 10.1016/j.bone.2013.01.025

Figure 3. PTHrP Signaling Induces TRAP Expression in Osteocytes during Lactation.

Figure 3

A) TRAP staining is positive in osteocytes in the tibia during lactation but is lost in osteocytes 7 days after pups are weaned. Graph shows the percentage of TRAP-positive osteocytes at each stage. B) Unloading the skeleton does not induce TRAP staining despite rapid bone loss. C) Infusion of PTHrP into virgin mice induces TRAP staining in osteocytes from both cortical and trabecular bone, reproducing the effects of lactation. (reproduced from Qing et al, J Bone Miner Res 27:1018–1029, 2012 with permission)