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. Author manuscript; available in PMC: 2013 Apr 12.
Published in final edited form as: Nat Genet. 2011 Jan 16;43(2):147–152. doi: 10.1038/ng.752

Figure 1. Btbd12 deficiency results in growth retardation and compromised fertility.

Figure 1

a) A representative image of Btbd12+/+ and Btbd12−/− littermates at 7 weeks revealing obvious growth retardation. b) Weights of male and female Btbd12+/+, Btbd12+/−, and Btbd12−/− animals at 12 weeks confirming growth retardation of Btbd12−/− mice. (n=10 for each genotype, central line represents median, box interquartile range, whiskers 90th centiles, *** p<0.001, ** p<0.01.) c) Microscopic analysis of H&E stained sections of ovary (x400, scale bar 50μm), testis (x50, scale bar 400μm) and epididymis (x400, scale bar 50μm) from Btbd12+/+, Btbd12−/− and Fanca−/− animals at 16 weeks. This revealed absence of oocyte maturation in Btbd12−/− females, and similar pattern of impaired spermatogenesis in testis of Btbd12−/− and Fanca−/− mice with absence of spermatozoa from epididymis.