Table 1.
Serum metabolite values and body temperature for 3- to 5-month-old overnight-fasted control and Acot7N−/− male and female micea
| Parameter | Value for group (nb) |
|||
|---|---|---|---|---|
| Female |
Male |
|||
| Control (5) | Acot7N−/− (6) | Control (7) | Acot7N−/− (8) | |
| β-HB (mmol/liter) | 1.8 ± 0.2 | 3.1 ± 0.4* | 1.2 ± 0.2 | 1.9 ± 0.2* |
| TAG (mg/dl) | 9.8 ± 1.9 | 22.7 ± 4.9* | 25.6 ± 3.8 | 36.1 ± 1.4* |
| Glycerol (mg/dl) | 24.8 ± 4.4 | 21.9 ± 1.3 | 24.6 ± 3.9 | 29.8 ± 2.6 |
| NEFA (mmol/liter) | 0.84 ± 0.06 | 1.17 ± 0.1* | 0.75 ± 0.18 | 0.8 ± 0.12 |
| Cholesterol (mg/dl) | 71.6 ± 2.7 | 64.8 ± 6.1 | 94.3 ± 7.3 | 102.2 ± 9.0 |
| Glucose (mg/dl) | 66 ± 5 | 68 ± 3 | 65 ± 2 | 70 ± 6 |
| Body temp (°C) | 34.5 ± 0.5 | 36.5 ± 0.3* | 34.7 ± 0.3 | 35.7 ± 0.4 |
| Creatine kinase (U/liter) | 7,738 ± 370 | 6,934 ± 1,399 | 9,404 ± 568 | 9,437 ± 698 |
a
β-HB, beta-hydroxybutryate; TAG, triacylglycerol; NEFA, nonesterified fatty acids. Data represent averages ± SE. “∗” indicates P ≤ 0.05 by a two-tailed Student t test comparing controls to Acot7N−/− mice within sex.
b
n, no. of mice.