Table 1.
CTL escape mutations in HIV-1B Gag
| Escape mutationa | Gag protein | Associated HLA class I alleleb | CTL epitopec | Epitope sequenced |
|---|---|---|---|---|
| K26R | p17 | B*08 (nonprotective) | B*08-GK9 | GGKKKYKLK |
| K28R | p17 | A*03 (nonprotective) | A*03-RK9 | RLRPGGKKK |
| K28Q | p17 | A*03 (nonprotective) | A*03-RK9 | RLRPGGKKK |
| Y79F | p17 | A*01(nonprotective) | A*01-GY9 | GSEELRSLY |
| Y79H | p17 | Cw14 (protective) | Cw14-LL8 | LYNTVATL |
| A81T* | p17 | B*08 (nonprotective) | B*08-EV8 | ELRSLYNTV |
| A83V | p17 | A*11 (nonprotective) | A*11-TI9 | [A]TLYCVHQR |
| R91G | p17 | A*11 (nonprotective) | A*11-TK8 | TLYCVHQR |
| A146P | p24 | B*57 (protective) | B*57-ISW9 | [A]ISPRTLNAW |
| I147L | p24 | A*25 (protective) | A*25-QW11 | QAISPRTLNAW |
| A163G | p24 | B*57 (protective) | B*57-KF11 | KAFSPEVIPMF |
| Q182T | p24 | B*42 (undetermined) | B*42-TL9 | TPQDLNTML |
| T186M | p24 | Cw08 (protective) | Cw08-TL9 | TPQDLNTML |
| E211D | p24 | A*25 (protective) | A*25-EW10 | ETINEEAAEW |
| T242N | p24 | B*57 (protective) | B*57-TW10 | TSTLQEQIGW |
| G248A | p24 | B*57 (protective) | B*57-TW10 | TSTLQEQIGW |
| D260E* | p24 | B*35 (nonprotective) | B*35-NY10 | NPPIPVGEIY |
| R264K | p24 | B*27 (protective) | B*27-KK10 | KRWIILGLNK |
| L268M | p24 | B*27 (protective) | B*27-KK10 | KRWIILGLNK |
| T280S | p24 | B*52 (protective) | B*52-RI8 | RMYSPTSI |
| K302R | p24 | B*14 (protective) | B*14-DA9 | DRFYKTLRA |
| T303V | p24 | B*14 (protective) | B*14-DA9 | DRFYKTLRA |
| D312E* | p24 | B*44 (nonprotective) | B*44-AW11 | AEQASQEVKNW |
| K331R | p24 | B*08 (nonprotective) | B*08-DL9 | DCKTILKAL |
| G357S | p24 | A*11 (nonprotective) | A*11-AK11 | ACQGVGGPGHK |
| T427N | p7 | B*40 (protective) | B*40-TL8 | TERQANFL |
| K436R | p1 | B*13 (protective) | B*13-RI9 | RQANFLGKI |
| I437L | p1 | B*13 (protective) | B*13-RI9 | RQANFLGKI |
| E482D | p6 | B*40 (protective) | B*40-KL9 | KELYPLTSL |
a
CTL escape mutation denoted as susceptible residue followed by position (HXB2 Gag numbering) followed by escape residue; an asterisk denotes a putative negatope escape mutation.
b
HLA class I allele associated with mutation expression in HIV-1B (56) and its protective value in HIV-1 infection (10).
c
Defined CTL epitope spanning or immediately adjacent to the listed escape mutation.
d
HIV-1B consensus sequence for each epitope; position of escape mutation underlined; brackets denote mutation adjacent to epitope.