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. 2013 Apr;87(7):3979–3989. doi: 10.1128/JVI.03473-12

Table 1.

A summary of similarities in stability between common and rare fragile sites and HPV episomes

Treatment Stability of fragile site in indicated categorya
HPV stabilityb Reference(s)
Common Rare
Aphidicolin Yes Yes Yes (49, 50)
ATM dependent No No No, yesb (51)
ATR dependent Yes Yes Yes (51, 52)
Chk1 dependent Yes Yes (53)
Chk2 dependent No No (53)
Distamycin sensitive No Yes Yes (19, 54)
AT-rich DNA Yes Yes Yes (48)
a

Treatment/gene effect on loss of common and rare fragile site stability. —, not reported.

b

Treatment/gene effect causes loss of HPV episome stability.

cATM siRNA but not ATM inhibitor causes episome loss.