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Ad vector expression is highly variable between mouse strains. (A) BALB/c mice, C57BL/6 mice, and their F1 progeny (CB6F1) were injected i.v. with 1 × 1010 vp of Ad5 or Ad5/6. After 24 h, light output was quantified as a measure of luciferase expression (n, 10 to 18). (B) BALB/c mice, unshaved or shaved C57BL/6 mice, and albino C57BL/6 mice were injected i.v. with 1 × 1010 vp of Ad5 or Ad5/6. *, P < 0.05; ***, P < 0.001; ns, not significant.
