Fig 4.

Group I PAKs are involved in US3-mediated suppression of S3 cofilin phosphorylation. (A and B) ST cells treated with or without 33 μM group I PAK inhibitor IPA-3 were either mock inoculated (A) or inoculated with WT PRV (B). At 6 hpi, total cell lysates were subjected to Western blotting to detect phospho-S3 cofilin, total cofilin, and US3. Values were normalized to mock (A) or to PRV and IPA-3 (B). The graphs represent the means + standard errors of the means from three independent experiments, with * indicating P values of <0.05.