Table 1.
Revertant group | S57 residue | Second site(s) | No. of independent isolates |
---|---|---|---|
S57D revertants | A | None | 2 |
G | None | 2 | |
G | E1 Q196H | 1 | |
G | E1 D109Y | 1 | |
S57K revertants | Q | None | 6 |
A | None | 1 | |
S | None | 1 | |
Sa | None | 1 | |
N | None | 2 | |
N | E2 S1I | 1 | |
N | E2 H170Y | 1 | |
K | E2 H170Y, M171T | 1 |
Two independent serine revertants were isolated, each with distinct codon changes that differed from the WT virus sequence.