Table 2.
Fold changes in the mRNA levels of inflammatory molecules in the brains of WNV-infected WT and ASC−/− mice
| Gene | mRNA fold changea |
|
|---|---|---|
| WT | ASC−/− | |
| Casp1 | 5.01 ± 0.35 | 2.64 ± 0.45 |
| Ccl2 (MCP-1) | 85.92 ± 10.20 | 588.13 ± 31.61 |
| Ccl3 (MIP-α) | 6.17 ± 0.67 | 55.72 ± 2.52 |
| Ccl4 (MIP-β) | 23.02 ± 1.21 | 84.45 ± 4.82 |
| Ccl5 (RANTES) | 52.89 ± 4.23 | 90.51 ± 10.50 |
| Ccr1 | 7.09 ± 0.42 | 9.85 ± 1.16 |
| Ccr4 | 1.17 ± 0.04 | 3.48 ± 0.30 |
| Ccr7 | 1.77 ± 0.16 | 6.06 ± 0.76 |
| Cxcl10 (IP-10) | 641.36 ± 13.34 | 831.75 ± 37.13 |
| Cxcl11 (IP-9) | 9.35 ± 0.85 | 45.25 ± 0.4 |
| IFN-γ | 11.51 ± 1.51 | 18.38 ± 1.98 |
| IL-10 | 18.70 ± 2.64 | 10.56 ± 1.05 |
| IL-4 | 3.80 ± 0.41 | 1.87 ± 0.05 |
| TNF-α | 13.22 ± 1.1 | 22.63 ± 2.13 |
a
The data are expressed as means ± standard deviations for a total of four animals from two independent arrays for each group.