Table 1.

Posttranslational modifications of human CCaX motif-containing proteins^a,^b

Protein	CCaX	Prenylationc	Palmitoylation	Methylation	Reference(s) and source or accession no.
bCdc42	CCIF	GG/Far	+	+	21, this study
Wrch-1	CCFV	−	+d		22
RalA	CCIL	GG	+	+	26, 29, this study
RalB	CCLL	GG	+		29, this study
PRL-1	CCIQ	Far			30
PRL-2	CCVQ	Far			30
PRL-3	CCVM	Far	+	+	30, this study
PDE6α	CCIQ	Far		+	41
PDE6β	CCIL	GG		+e	41
PLA2γ	CCLA	Far	+f		44
SLFNL1	CCVL	?	?	?	NP_001161719
ASPA	CCLH	?	?	?	NP_000040
MPI	CCLL	?	?	?	NP_002426

^aThe list of proteins was derived from known and hypothetical CaaX prenyltransferase substrates (60) and PRENbase (http://mendel.imp.ac.at/PrePS/PRENbase/).

^bModifications identified in this study are in boldface type.

^cFar, farnesylation; GG, geranylgeranylation.

^dThe second cysteine of the CCFV motif of Wrch-1 is palmitoylated.

^eCarboxymethylation of PDE6β is approximately 20 times lower than that of PDE6α.

^fThe palmitoylation site(s) of PLA2γ was not identified.