Fig 1.

Schematic representation of PTP61Fm and PTP61Fn. The two PTP61F variants are identical except for their extreme C termini. The PTP61Fm hydrophobic C-terminal tail that targets PTP61Fm to membranes, including the ER (35), is shown. Basic residues in the PTP61Fn C terminus shown in bold are thought to constitute a nuclear localization sequence (NLS) targeting PTP61Fn to the nucleus (35). The PTP catalytic domain and the PXXP motifs that are present in both variants and allow interaction with SH3 domain-containing proteins are also highlighted.