Table 4.
Summary of the pseudoviruses neutralized by PG9-aplaviroc with IC80s of <50 μg/ml that are not neutralized by PG9 (IC80s, >50 μg/ml)
| Virus IDa | Cladeb | IC80 titer in TZM-bl cells (μg/ml)c |
|
|---|---|---|---|
| PG9 | PG9-aplaviroc | ||
| WEAU_d15_410_5017 | B (T/F) | >50 | 19.772 |
| HIV-16845-2.22 | C | >50 | 18.415 |
| 620345.c01 | CRF01_AE | >50 | 14.409 |
| 0815.v3.c3 | ACD | >50 | 7.406 |
| 6480.v4.c25 | CD | >50 | 8.097 |
| 6952.v1.c20 | CD | >50 | 11.544 |
| 6811.v7.c18 | CD | >50 | 24.897 |
| X2088_c9 | G | >50 | 30.361 |
| 3016.v5.c45 | D | >50 | 1.571 |
| 191821_E6_1 | D (T/F) | >50 | 0.976 |
| 246F C1G | C (T/F) | >50 | 3.500 |
| 7030102001E5(Rev-) | C (T/F) | >50 | 29.579 |
| CNE30 | BC | >50 | 41.902 |
| Ce1086_B2 | C (T/F) | >50 | 4.069 |
| ZM214M.PL15 | C | >50 | 18.933 |
| PVO.4 | B | >50 | 8.239 |
| TRO.11 | B | >50 | 35.584 |
| RHPA4259.7 | B | >50 | 7.092 |
| THRO4156.18 | B | >50 | 20.071 |
| 1054_07_TC4_1499 | B (T/F) | >50 | 36.094 |
| 6244_13_B5_4576 | B (T/F) | >50 | 28.640 |
| 62357_14_D3_4589 | B (T/F) | >50 | 17.254 |
a
ID, identification.
b
T/F, transmitted/founder virus.
c
The PG9 data are historical data for this 117-virus panel bridged for the current experiment with a set of representative viruses. For PG9-aplaviroc, the median IC80 titer in TZM-bl cells is 17.834 μg/ml, and the mean ± standard deviation is 17.655 ± 12.160 μg/ml.