Fig 7.

Vaccination with VRP-SUDV GP protects cynomolgus macaques from SUDV aerosol challenge. NHPs were vaccinated with one (A and C) or two (B and D) doses of VRP expressing irrelevant antigen or VRP expressing SUDV GP. SUDV GP specific serum antibody end titers were determined by ELISA at the indicated times postvaccination with one (A) or two (B) doses of vaccine. Dotted line indicates assay limit of detection. (C) NHPs receiving one dose of irrelevant VRP (n = 1) or VRP-SUDV GP (n = 3) were challenged by aerosol exposure to 100 PFU of SUDV 28 days postvaccination. (D) NHPs receiving two doses of irrelevant VRP (n = 3) or VRP-SUDV GP (n = 3) were challenged by aerosol exposure to 100 PFU of SUDV 28 days following the second vaccination. **, P ≤ 0.01 (as determined by the Fisher exact test).