Table 3.
VRP-SUDV GP-vaccinated macaques after aerosol filovirus challenge
| NHPa | Adverse events on days 1 to 28 after challengeb | Status |
|---|---|---|
| Ctrl 9 | Depression (days 7 and 8), widespread rash (days 7 and 8), anorexia (days 7 and 8) viremia (days 3, 5, and 7), thrombocytopenia (days 3, 5, and 7), 2- to 3-fold increase in ALT and ALP, >5-fold increase in AST, 2- to 3-fold decrease in AMY | Succumbed on day 9 |
| Ctrl 10 | Depression (days 6 to 8), widespread rash (days 6 and 7), anorexia (days 7 and 8), viremia (days 3, 5, and 7), thrombocytopenia (days 5 and 7), >5-fold increase in AST | Succumbed on day 9 |
| Ctrl 11 | Fever (day 7), depression (days 7 to 9), widespread rash (days 8 and 9), anorexia (days 8 and 9), bleeding from nose (day 9), viremia (days 5 and 7), thrombocytopenia (days 5, 7, and 9), 2- to 3-fold increase in ALP, >5-fold increase in ALT and AST | Succumbed on day 9 |
| Ctrl 12 | Depression (days 6 and 7), widespread rash (day 7), anorexia (days 6 and 7), viremia (days 5 and 7), thrombocytopenia (days 5 and 7), >5-fold increase in ALT and ALP | Succumbed on day 7 |
| Exp 13 | Fever (day 5), depression (days 6 and 7), mild rash (day 7), anorexia (day 7), viremia (day 7), thrombocytopenia (days 3, 5, and 7), 2- to 3-fold increase in AST (day 7), 2- to 3-fold decrease in AMY | Succumbed on day 8 |
| Exp 14 | Depression (day 7), widespread rash (day 7), anorexia (day 7), viremia (day7), thrombocytopenia (day 7), 4- to 5-fold increase in ALT, >5-fold increase in AST and ALP, 2- to 3-fold decrease in AMY | Succumbed on day 8 |
| Exp 15 | Depression (day 6), mild rash (day 6), anorexia (day 6), thrombocytopenia (days 3 and 5), 2- to 3-fold decrease in AMY | Succumbed on day 7 |
| Exp 16 | Fever (day 10), depression (days 9 to 12), anorexia (days 9 to 12) | Survived |
| Exp 17 | No clinical signs | Survived |
| Exp 18 | Depression (days 6 to 14), anorexia (days 6 to 14), viremia (day 5), 2- to 3-fold increase in ALP | Survived |
a
Ctrl, control animals; Exp, experimental animals. All animals were challenged with 100 PFU of SUDV by aerosol.
b
ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; AMY, amylase.