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Type I IFN production is mediated through both RIG-I and MDA5. cDCs from wild-type or mice deficient in RIG-I (A) or MDA5 (B) were infected with rMP-12 or NSs del at an MOI of 1 for 6, 12, or 24 h. IFN-α levels in supernatants were measured by ELISA. All results are means ± the standard deviations (n = 3). Significance: *, P ≤ 0.05.
