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Low-dose JE-ADVAX vaccine exerts long-term protection against JEV challenge. Six-week-old β2m−/− mice were immunized with two doses of ccJE (0.05 μg/dose) plus Advax (1 mg/dose) given 2 weeks apart, and a negative-control group was injected with PBS. At 6 months after the last dose, mice were challenged s.c. with 103 PFU of JEV. Mice were monitored twice daily for morbidity and mortality over a 28-day-observation period. The asterisk denotes statistical significance (*, P < 0.05).
