Table 3.

Hits detected in MAPK pathways by using the DAVID algorithm

Gene symbol	Gene name	SSMD
RPS6KA1	Ribosomal protein S6 kinase, 90 kDa, polypeptide 1	7.06
MAP3K6	Mitogen-activated protein kinase kinase kinase 6	6.89
PRKACG	Protein kinase, cAMP dependent, catalytic, gamma	6.86
MAP3K7IP2	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2	6.83
MOS	v-mos Moloney murine sarcoma viral oncogene homolog	6.76
PDGFRA	Platelet-derived growth factor receptor, alpha polypeptide	6.41
MAP2K7	Mitogen-activated protein kinase kinase 7	6.14
PLA2G2A	Phospholipase A2, group IIA (platelets, synovial fluid)	5.83
MAPKAPK2	Mitogen-activated protein kinase-activated protein kinase 2	5.65
PPP3CC	Protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform	5.62
DUSP6	Dual-specificity phosphatase 6	5.56
MAP4K1	Mitogen-activated protein kinase kinase kinase kinase 1	5.36
BDNF	Brain-derived neurotrophic factor	5.26
CACNG3	Calcium channel, voltage dependent, gamma subunit 3	5.12
PLA2G1B	Phospholipase A2, group IB (pancreas)	5.03
MAP3K3	Mitogen-activated protein kinase kinase kinase 3	4.99
TAOK3	TAO kinase 3	4.48
SOS1	Son of sevenless homolog 1 (Drosophila)	4.37
DUSP5	Dual-specificity phosphatase 5	4.23
CACNB1	Calcium channel, voltage dependent, beta 1 subunit	4.08
RPS6KA6	Ribosomal protein S6 kinase, 90 kDa, polypeptide 6	−3.41
CDC25B	Cell division cycle 25 homolog B (S. pombe)	−5.26
MAP3K8	Mitogen-activated protein kinase kinase kinase 8	−5.77
MAPK7	Mitogen-activated protein kinase 7	−6.29
RPS6KA3	Ribosomal protein S6 kinase, 90 kDa, polypeptide 3	−6.31
PAK1	p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)	−6.92
MAPK3	Mitogen-activated protein kinase 3 (ERK1)	−7.39
PDGFRB	Platelet-derived growth factor receptor, beta polypeptide	−7.81
MAP2K4	Mitogen-activated protein kinase kinase 4	−7.96
MAPK10	Mitogen-activated protein kinase 10	−11.32