Fig 2.

A serially passaged Sin Nombre virus establishes disseminated infection in hamsters. Immunohistochemistry revealed the presence of hantaviral antigen in all organs collected from hamsters infected with the passaged (hamster-adapted) Sin Nombre virus. Shown are kidney, spleen, liver, and heart samples from a representative animal infected with the p5 (left) and p20 (right) variants. Viral antigen was detected in glomerular endothelium (arrow) and endothelial cells lining capillaries in the renal interstitial space between proximal tubules (open arrow) of the kidneys, numerous mononuclear cells within the splenic marginal zones (arrow), in endothelial cells of portal veins (arrow) and endothelial cells lining hepatic sinusoids (open arrows) of the liver, and in endothelial cells lining capillaries between cardiomyofibers (arrows) of the heart.