Fig 4.

Immunofluorescence staining for endothelial cell markers and hantaviral antigen in hamster lungs. Lung samples collected 9 days postinfection were costained for endothelial cell markers (CD31, green) and hantavirus nucleoprotein antigen (red). Lung specimens from hamsters infected with a hamster-adapted (passage 5) Sin Nombre virus (A) and Andes virus (B) exhibited the presence of hantaviral antigen in cells positive for CD31, supporting the notion that both viruses replicate in pulmonary endothelial cells.