Table 1.
HCV epitope sequence during early acute and during chronic HCV infections
| Chimpanzee (infection outcome) | Epitope locationa | Wk after infectionb | Amino acid sequencec | No. of clones with indicated sequence/no. of clones sequenced |
|---|---|---|---|---|
| Ch6461 (self limited) | NS31278–1285 | 0 | GVDPNIRTGVRTITTGSP | |
| 8* | ------------------ | 17/17 | ||
| NS5A2290–2298 | 0 | LPVWARPDYNPPLVETWKK | ||
| 8* | ------------------- | 22/24 | ||
| -----Q------------- | 1/24 | |||
| ----------L-------- | 1/24 | |||
| Ch6455 (self limited) | NS31359–1367 | 0 | SVTVSHPNIEEVALSTTGE | |
| 8* | ------------------- | 16/18 | ||
| --I---------------- | 1/18 | |||
| ------------------R | 1/18 | |||
| Ch6411 (chronic) | E2588–596 | 0 | TDCFRKHPEATYSRCGSGP | |
| 9* | ------------------- | 22/23 | ||
| -------L----------- | 1/23 | |||
| 26 | ------------------- | 7/21 | ||
| ---------T--------- | 11/21 | |||
| ----------L-------- | 1/21 | |||
| ----------S-------- | 1/21 | |||
| -----T---T--------- | 1/21 | |||
| Ch6412 (chronic) | NS31359–1367 | 0 | SVTVSHPNIEEVALSTTGE | |
| 11* | ------------------- | 24/24 | ||
| 26 | ----P-------------- | 23/23 |
a
NS31278 and NS5A2290 are Patr-B*0301/02 restricted, NS31359 is Patr-B*1301 restricted, and E2588 is Patr-A*0401 restricted.
b
The HCV sequence that is indicated for the week 0 time point is the sequence of the HCV inoculum. *, first time point at which tetramer+ CD8 T cells were detected in the blood.
c
The epitope sequence is in boldface and underlined. Hyphens indicate amino acids identical to those at inoculation.