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. 2013 Feb 20;288(15):10275–10285. doi: 10.1074/jbc.M112.416719

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Defect of the optic stalk morphogenesis in Smad7 mutant mice. The eyes of the control and Smad7-deficient embryos were used in in situ hybridization to analyze expression of genes involved in optic stalk morphogenesis, including a transverse view of Pax2 (A and B), a sagittal view of Pax2 in the optic stalk (C and D), and a transverse view of Vax1 (E and F), Vax2 (G and H), Rx (I and J), Pax6 (K and L), Mitf (M and N), and shh (O and P) at different stages of embryonic development. Scale bars: 50 μm (A–N) and 100 μm (O and P).