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Retarded retinal neurogenesis in Smad7 null mice. In situ hybridization analysis of genes involved in retinal growth and differentiation, including Math5 (A–F), Fgf15 (G and H), and Brn3b (I and J). Neural marker Tuj1 was examined by immunohistochemistry (K and L). Note that no Tuj1 signal was detected in the central retina in the mutant mice (marked by arrow), where the neural cell was initiated in the wild type control (marked by arrowhead). Scale bar: 50 μm.
