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. 2013 Mar 4;288(15):10440–10450. doi: 10.1074/jbc.M112.432286

FIGURE 1.

FIGURE 1.

Expression of Tak1 in the developing palate and tongue. A, B, D, and E, Tak1 protein is present in the palatal epithelium and mesenchyme in the anterior and posterior domain of E12.5 and E13.5 wild type palatal shelves. G and H, Tak1 expression is also seen in the peripheral mesenchymal cells (white arrows) and lingual septum area (red arrows) of the wild type developing tongue at E12.5 and E13.5. C, F, and I, Tak1 protein is dramatically reduced or almost undetectable in the palatal mesenchyme and the tongue of E13.5 Wnt1-Cre;Tak1F/F embryo. Note that Tak1 protein remains in the palatal epithelium of the mutant. J, negative control for immunohistochemistry. K, LacZ staining shows population of CNC-derived cells in the peripheral mesenchymal region (black arrows) and the lingual septum domain (red arrow) in the tongue of E13.5 Wnt1-Cre;R26R embryo.