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. 2013 Mar 4;288(15):10440–10450. doi: 10.1074/jbc.M112.432286

FIGURE 2.

FIGURE 2.

Deletion of Tak1 in the CNC lineage leads to failed elevation of secondary palate and a complete clefting. A and B, whole mount views of E18.5 wild type (A) and Wnt1-Cre;Tak1F/F (B) mice show a completely clefting of the secondary palate in mutant. C–F, histological sections show comparable morphology of control (C and E) and mutant (D, F) palatal shelves at both the anterior and posterior domains at E13.5. G–N, histological sections show failed elevation of palatal shelves at E14.5 and E16.5 in Wnt1-Cre;Tak1F/F mice (H, J, L, and N) compared with stage-matched controls (G, I, K, and M). T, tongue; PP, primary palate; PS, palatal shelf. Scale bars, 100 μm (C–J), 500 μm (K–N).