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Tak1 is not an intrinsic regulator of palatal shelf elevation. A and B, histological sections show palatal shelf elevation in E13.5 wild type (A) and Wnt1-Cre;Tak1F/F (B) embryonic head with removal of the mandible after 24 h in roller culture. C and D, histological sections show elevation and contact of palatal shelves in wild type (C) and Wnt1-Cre;Tak1F/F (D) embryonic head with removal of the tongue after 24 h in roller culture. M, Meckel's cartilage; PS, palatal shelf.
