FIGURE 9.

Failed palate elevation associated with heightened tongue in mice overexpressing Fgf10 in the tongue. A–E, comparison of tongue height through mid-level of tongues of E14.5 control (A and C) and Wnt1-Cre;pMes-Fgf10 (B and D) mice reveals a heightened tongue in the transgenic animal (E). F–J, BrdU labeling shows enhanced cell proliferation rate in E13.5 and E14.5 Wnt1-Cre;pMes-Fgf10 tongue compared with controls. Total and BrdU-positive cells in the entire tongue of nine sections from three samples for each stage were counted. *, p < 0.05. Scale bars, 200-μm. Error bars, S.E.