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PKAc has a C-terminal tail that extends around the catalytic domain. PKAc, shown in cartoon representation, has an N-domain (top) and a larger C-domain (bottom). The C-terminal tail comprises the N-terminal lobe tether (purple), the AST (magenta), and the C-terminal lobe tether (gold). Tyr-330 and ATP are shown in vector representation. ATP is coordinated by two manganese ions shown as green spheres.
