Fig 2.
Degradation pathway of DTDP. DTDP is initially cleaved by an NADH-dependent disulfide reductase (LpdA) (20), yielding two molecules of 3MP, which are further oxygenated by a dioxygenase (Mdo) (21), yielding 3SP. The latter is activated by succinate-CoA ligase (SucCD) (22) to the corresponding CoA thioester. 3SP-CoA desulfinase (AcdDPN7) catalyzes the final desulfination step, releasing sulfite with the concomitant formation of propionyl-CoA, which subsequently enters the central metabolism via the methyl citric acid cycle.