Fig 1.

Overview of the genomic organization of hexose-6P uptake systems in V. cholerae and E. coli. The genomic region of E. coli responsible for hexose-6P uptake consists of three regulatory genes, uhpA, uhpB, and uhpC, that control the expression of the corresponding transport protein UhpT (42). In V. cholerae, homologous genes are located on the small chromosome and are similarly arranged. They are regulatory genes uhpA/VCA0682, uhpB/VCA0683, and uhpC/VCA0684. While no uhpT homologue is found in V. cholerae, three additional genes are present: VCA0685 (substrate-binding protein [bind. prot.]), VCA0686 (permease), and VCA0687 (ATPase). According to NCBI BLASTP (57), V. cholerae ORFs VCA0682 to VCA0684 show amino acid identities to corresponding E. coli K-12 proteins, as indicated at the bottom.