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Overexpression of the outer membrane lipoprotein NlpE activates the Cpx response, which is sufficient to confer resistance to hydroxyurea (HU). (A) Survival of strains was measured by enumerating CFU on LB agar plates supplemented with increasing concentrations of HU. (B) EOP assay (as described in the legend to Fig. 1) of E. coli strains MC4100, PTM163 (cpxA*), PTM202 (NlpE overexpressed [NlpE O/E]), and PTM208 (NlpE O/E cpxR D51A) on 15 mM HU.
