Figure 2.

Positions of missense mutations in PROK2 and PROKR2 in the structural models of the ligand and the receptor. The mutations are classified in different categories according to their effects on PROKR2 signaling activity: similar to wild-type (green), absence of the receptor at the cell surface (brown), absence of ligand-binding (blue), and strong or mild effect on signaling (red and orange, respectively). The mutations for which functional data are not available are denoted in black. The colored balls indicate the atom of alpha carbon of the polypeptidic chain of the mutated residue. Note that residue R357 is located in the proximal part of the C-terminal region of the receptor.